Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans

@inproceedings{Shipley2014SimultaneousOM,
  title={Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans},
  author={Frederick B. Shipley and Christopher Michael Clark and Mark J. Alkema and Andrew M. Leifer},
  booktitle={Front. Neural Circuits},
  year={2014}
}
Understanding how an organism's nervous system transforms sensory input into behavioral outputs requires recording and manipulating its neural activity during unrestrained behavior. Here we present an instrument to simultaneously monitor and manipulate neural activity while observing behavior in a freely moving animal, the nematode Caenorhabditis elegans. Neural activity is recorded optically from cells expressing a calcium indicator, GCaMP3. Neural activity is manipulated optically by… CONTINUE READING
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Simultaneous optogenetic manipulation and calcium imaging in freely moving C

  • FB Citation Shipley, CM Clark, MJ Alkema, AM Leifer
  • elegans. Front. Neural Circuits 8:28. doi: 10…
  • 2014

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