Simultaneous optimization of the resolution and analysis time in micellar liquid chromatography of phenyl thiohydantoin amino acids using Derringer's desirability function.

@article{Safa2005SimultaneousOO,
  title={Simultaneous optimization of the resolution and analysis time in micellar liquid chromatography of phenyl thiohydantoin amino acids using Derringer's desirability function.},
  author={Fariba Safa and Mohammad Reza Hadjmohammadi},
  journal={Journal of chromatography. A},
  year={2005},
  volume={1078 1-2},
  pages={42-50}
}
The chemometrics approach was applied for simultaneous optimization of resolution and analysis time of nine phenyl thiohydantoin amino acids in micellar liquid chromatography. Derringer's desirability function, a multi-criteria decision making method, was tested for the evaluation of the two different chromatographic performance goals. The effect of five experimental parameters on a chromatographic response function formed using two sigmoidal desirability functions was investigated. The… CONTINUE READING