Simultaneous optimization of percutaneous delivery and adhesion for ketoprofen poultice.

@article{Sheu1999SimultaneousOO,
  title={Simultaneous optimization of percutaneous delivery and adhesion for ketoprofen poultice.},
  author={Ming Thau Sheu and Ling Chen and Hsiu O. Ho},
  journal={International journal of pharmaceutics},
  year={1999},
  volume={233 1-2},
  pages={
          257-62
        }
}
Topical poultices of ketoprofen were prepared using deionized water, propylene glycol (X1), and glycerin (X2) as the vehicle in combination with hydrophilic matrix materials, including gelatin (X3) and sodium polyacrylate. A mixture design was utilized to evaluate the influence of these constituents (X1-X3) on the adhesion of the poultice and the percutaneous penetration of ketoprofen from poultices. The adhesion of the poultice was measured based on the L-Peel test method using a Tensile and… CONTINUE READING
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