Simultaneous optimization of dose distributions and fractionation schemes in particle radiotherapy.

@article{Unkelbach2013SimultaneousOO,
  title={Simultaneous optimization of dose distributions and fractionation schemes in particle radiotherapy.},
  author={Jan Unkelbach and Chuan Zeng and Martijn Engelsman},
  journal={Medical physics},
  year={2013},
  volume={40 9},
  pages={091702}
}
PURPOSE The paper considers the fractionation problem in intensity modulated proton therapy (IMPT). Conventionally, IMPT fields are optimized independently of the fractionation scheme. In this work, we discuss the simultaneous optimization of fractionation scheme and pencil beam intensities. METHODS This is performed by allowing for distinct pencil beam intensities in each fraction, which are optimized using objective and constraint functions based on biologically equivalent dose (BED). The… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-8 of 8 references

Utility of normal tissuetotumor a / b ratio when evaluating isodoses of isoeffective radiation therapy treatment plans

  • J. Y. Jin, A. J. Chang, R. K. Ten Haken
  • Phys . Med . Biol .
  • 2013

Fractionation schedule optimization for lung cancer treatments using radiobiological and dose distribution characteristics

  • G. Meier H. Keller, A. Hope, M. Davison
  • Int . J . Radiat . Oncol . , Biol . , Phys .
  • 2012

The dependence of optimal fractionation schemes on the spatial dose distribution

  • D. Craft J. Unkelbach, E. Salari, J. Ramakrishnan, T. Bortfeld
  • Med . Phys .
  • 2012

Isotoxic dose escalation by increasing tumor dose variance

  • A. Trofimov, T. Hong, M. Engelsman
  • Med . Phys .
  • 2005

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