Simultaneous optimization of dose distributions and fractionation schemes in particle radiotherapy.

  title={Simultaneous optimization of dose distributions and fractionation schemes in particle radiotherapy.},
  author={Jan Unkelbach and Chuan Zeng and Martijn Engelsman},
  journal={Medical physics},
  volume={40 9},
PURPOSE The paper considers the fractionation problem in intensity modulated proton therapy (IMPT). Conventionally, IMPT fields are optimized independently of the fractionation scheme. In this work, we discuss the simultaneous optimization of fractionation scheme and pencil beam intensities. METHODS This is performed by allowing for distinct pencil beam intensities in each fraction, which are optimized using objective and constraint functions based on biologically equivalent dose (BED). The… CONTINUE READING
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