Simultaneous optical mapping of transmembrane potential and wall motion in isolated, perfused whole hearts.

@article{Bourgeois2011SimultaneousOM,
  title={Simultaneous optical mapping of transmembrane potential and wall motion in isolated, perfused whole hearts.},
  author={Elliot B. Bourgeois and Andrew D. Bachtel and Jian Huang and Gregory P. Walcott and Jack M. Rogers},
  journal={Journal of biomedical optics},
  year={2011},
  volume={16 9},
  pages={096020}
}
Optical mapping of cardiac propagation has traditionally been hampered by motion artifact, chiefly due to changes in photodetector-to-tissue registration as the heart moves. We have developed an optical mapping technique to simultaneously record electrical waves and mechanical contraction in isolated hearts. This allows removal of motion artifact from transmembrane potential (V(m)) recordings without the use of electromechanical uncoupling agents and allows the interplay of electrical and… CONTINUE READING

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