Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry.

@article{Kantharaj2003SimultaneousMO,
  title={Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry.},
  author={Ethirajulu Kantharaj and An Tuytelaars and Pascale E A Proost and Zuleyha Ongel and Harrie P Van Assouw and Ron A. H. J. Gilissen},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2003},
  volume={17 23},
  pages={2661-8}
}
The use of in vitro drug metabolism data in the understanding of in vivo pharmacokinetic, safety and toxicity data has become a large area of scientific interest. This has stemmed from a trend in the pharmaceutical industry to use in vitro data generated from human tissue as a criterion to select compounds for further investigation. As well as measuring metabolic stability in vitro using human liver microsomal preparations, the identification of possible metabolite(s) formed may play a vital… CONTINUE READING

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