Simultaneous measurement of L-dopa, its metabolites and carbidopa in plasma of parkinsonian patients by improved sample pretreatment and high-performance liquid chromatographic determination.

Abstract

A procedure is described for the determination of L-3,4-dihydroxyphenylalanine (L-DOPA), its metabolites and carbidopa (CD) in plasma of Parkinsonian patients by high-performance liquid chromatography with dual working-electrode coulometric electrochemical detection. An efficient sample preparation scheme is presented for the isolation of L-DOPA, its… (More)

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@article{Lucarelli1990SimultaneousMO, title={Simultaneous measurement of L-dopa, its metabolites and carbidopa in plasma of parkinsonian patients by improved sample pretreatment and high-performance liquid chromatographic determination.}, author={Carla Lucarelli and Paola Betto and G Ricciarello and Massimo Giambenedetti and Carmen Corradini and Fabrizio Stocchi and Flavio Belliardo}, journal={Journal of chromatography}, year={1990}, volume={511}, pages={167-76} }