Simultaneous measurement of [3H]noradrenaline release and neurogenic contraction under identical conditions, to determine the prejunctional inhibitory effects of SKF 99101H and BRL 56905 in dog saphenous vein

@article{Medhurst1997SimultaneousMO,
  title={Simultaneous measurement of [3H]noradrenaline release and neurogenic contraction under identical conditions, to determine the prejunctional inhibitory effects of SKF 99101H and BRL 56905 in dog saphenous vein},
  author={A. Medhurst and A. Brown and A. Kaumann and A. A. Parsons},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1997},
  volume={355},
  pages={475-482}
}
Abstract Using a tissue bath system which allowed the simultaneous measurement of electrically-induced [3H]nor-adrenaline release and neurogenic contraction under identical conditions, we investigated the prejunctional inhibitory activity of the selective 5-HT1D/1B receptor agonists BRL 56905 ((±)-3-amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole) and SKF 99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate), compared to sumatriptan and 5-HT.Transmural electrical stimulation… Expand
5-HT Receptor Regulation of Neurotransmitter Release
Fine Tuning of Sympathetic Transmitter Release via Ionotropic and Metabotropic Presynaptic Receptors
Serotonin (5-HT) in Veins: Not All in Vain

References

SHOWING 1-10 OF 23 REFERENCES
Characterization of postjunctional alpha-1 and alpha-2 adrenoceptors activated by exogenous or nerve-released norepinephrine in the canine saphenous vein.
Accumulation and release of [3H]-5-hydroxytryptamine in saphenous veins and cerebral arteries of the dog.
A pre‐junctional action of 5‐hydroxytryptamine and methysergide on noradrenergic nerves in dog isolated saphenous vein
5-hydroxytryptamine and neurotransmitter release in canine blood vessels. Inhibition by low and augmentation by high concentrations.
  • M. McGrath
  • Chemistry, Medicine
  • Circulation research
  • 1977
Agonist potencies of tryptamine derivatives at pre- and postjunctional receptors in canine saphenous vein.
PRESYNAPTIC INHIBITORY ACTION OF 5‐HYDROXYTRYPTAMINE IN DOG ISOLATED SAPHENOUS VEIN
Denervation augments alpha-2 but not alpha-1 adrenergic responses in canine saphenous veins.
Presynaptic 5-HT auto- and heteroreceptors in the human central and peripheral nervous system
5-HT 1D receptors mediate SKF 99101H-induced hypothermia in the guinea pig
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