Simultaneous mapping of epistatic QTL in DU6i × DBA/2 mice

@article{Carlborg2004SimultaneousMO,
  title={Simultaneous mapping of epistatic QTL in DU6i × DBA/2 mice},
  author={{\"O}rjan Carlborg and Gudrun A. Brockmann and Chris S. Haley},
  journal={Mammalian Genome},
  year={2004},
  volume={16},
  pages={481-494}
}
We have mapped epistatic quantitative trait loci (QTL) in an F2 cross between DU6i × DBA/2 mice. By including these epistatic QTL and their interaction parameters in the genetic model, we were able to increase the genetic variance explained substantially (8.8%–128.3%) for several growth and body composition traits. We used an analysis method based on a simultaneous search for epistatic QTL pairs without assuming that the QTL had any effect individually. We were able to detect several QTL that… CONTINUE READING

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New methods for mapping quantitative trait loci

Ö Carlborg
Ph.D. thesis, Acta Universitatis Agriculturae Sueciae. Veterinaria 121. Swedish University of Agricultural Sciences, • 2002
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