Simultaneous inference of selection and population growth from patterns of variation in the human genome.

@article{Williamson2005SimultaneousIO,
  title={Simultaneous inference of selection and population growth from patterns of variation in the human genome.},
  author={Scott H. Williamson and Ryan D. Hernandez and Adi Fledel-Alon and Lan Zhu and R. Nielsen and Carlos Daniel Bustamante},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 22},
  pages={
          7882-7
        }
}
Natural selection and demographic forces can have similar effects on patterns of DNA polymorphism. Therefore, to infer selection from samples of DNA sequences, one must simultaneously account for demographic effects. Here we take a model-based approach to this problem by developing predictions for patterns of polymorphism in the presence of both population size change and natural selection. If data are available from different functional classes of variation, and a priori information suggests… CONTINUE READING
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