• Chemistry, Medicine
  • Published in Die Pharmazie 2007

Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract.

@article{Avula2007SimultaneousIA,
  title={Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract.},
  author={Bharathi Avula and Steven J. Dentali and Ikhlas A Khan},
  journal={Die Pharmazie},
  year={2007},
  volume={62 8},
  pages={
          593-6
        }
}
A HPLC method has been developed which permits the quantification of methyl paraben, benzethonium chloride and triclosan in various samples of grapefruit seed extract (GSE). The best results were obtained with a Phenomenex Gemini C18 column using gradient mobile phase of water (0.1% acetic acid) and acetonitrile (0.1% acetic acid) with a flow rate of 1.0 mL per minute. The detection wavelength was 254 nm for methyl paraben, and 275 nm for benzethonium chloride and triclosan. The main synthetic… CONTINUE READING