Simultaneous high-performance liquid chromatographic determination of antazoline phosphate and tetrahydrozoline hydrochloride in ophthalmic solution.

@article{Puglisi1986SimultaneousHL,
  title={Simultaneous high-performance liquid chromatographic determination of antazoline phosphate and tetrahydrozoline hydrochloride in ophthalmic solution.},
  author={Giuseppe Puglisi and S Sciuto and Rosa Chillemi and Sebastiano Mangiafico},
  journal={Journal of chromatography},
  year={1986},
  volume={369 1},
  pages={
          165-70
        }
}
A method for the determination of 2-[(N-phenyl)benzylaminomethyl]-2-imidazoline X H3PO4 (antazoline phosphate) and 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline X HCl (tetrahydrozoline hydrochloride) in ophthalmic solution is described. The pharmaceutical preparation is analysed directly by reversed-phase ion-pair high-performance liquid chromatography and the method is very rapid, selective and simple. 

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