Simultaneous high-performance liquid chromatographic determination of SCH 59884 (phosphate ester prodrug of SCH 56592), SCH 207962 and SCH 56592 in dog plasma.

@article{Kim2002SimultaneousHL,
  title={Simultaneous high-performance liquid chromatographic determination of SCH 59884 (phosphate ester prodrug of SCH 56592), SCH 207962 and SCH 56592 in dog plasma.},
  author={H. Kim and P. Kumari and C. Lin and A. Nomeir},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2002},
  volume={27 1-2},
  pages={
          295-303
        }
}
  • H. Kim, P. Kumari, +1 author A. Nomeir
  • Published 2002
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
SCH 59884 is an IV prodrug of SCH 56592, the broad-spectrum azole antifungal agent that is active both orally and intravenously in animal models of infection. SCH 56592 is in phase III clinical trials for the treatment of serious systemic fungal infections. SCH 59884 is a carboxylate ester of SCH 56592 with gamma-butyric acid phosphate. Following IV administration of SCH 59884, the compound is rapidly dephosphorylated to SCH 207962 which is then hydrolyzed to SCH 56592. A high-performance… Expand
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