Simultaneous glutamate and GABA(A) receptor agonist administration increases calbindin levels and prevents hippocampal damage induced by either agent alone in a model of perinatal brain injury.

Abstract

Perinatal brain injury is associated with the release of amino acids, principally glutamate and GABA, resulting in massive increases in intracellular calcium and eventual cell death. We have previously demonstrated that independent administration of kainic acid (KA), an AMPA/kainate receptor agonist, or muscimol, a GABA(A) receptor agonist, to newborn rats… (More)

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Cite this paper

@article{Hilton2005SimultaneousGA, title={Simultaneous glutamate and GABA(A) receptor agonist administration increases calbindin levels and prevents hippocampal damage induced by either agent alone in a model of perinatal brain injury.}, author={Genell D Hilton and Adanma N Ndubuizu and Joseph L. Nu{\~n}ez and Margaret M McCarthy}, journal={Brain research. Developmental brain research}, year={2005}, volume={159 2}, pages={99-111} }