Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays.

@article{Gingeras1998SimultaneousGA,
  title={Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays.},
  author={Thomas R. Gingeras and G. Ghandour and Ellen Y Wang and Anthony J. Berno and Peter M. Small and Francis A. Drobniewski and David Alland and Ed Desmond and Mark Holodniy and Jorg Drenkow},
  journal={Genome research},
  year={1998},
  volume={8 5},
  pages={435-48}
}
High-density oligonucleotide arrays can be used to rapidly examine large amounts of DNA sequence in a high throughput manner. An array designed to determine the specific nucleotide sequence of 705 bp of the rpoB gene of Mycobacterium tuberculosis accurately detected rifampin resistance associated with mutations of 44 clinical isolates of M. tuberculosis. The nucleotide sequence diversity in 121 Mycobacterial isolates (comprised of 10 species) was examined by both conventional dideoxynucleotide… CONTINUE READING