Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression

@article{Kawai2006SimultaneousGT,
  title={Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression},
  author={Mariko Kawai and Kazuhisa Bessho and Hiroki Maruyama and Jun-Ichi Miyazaki and Toshio Wako Yamamoto},
  journal={BMC Musculoskeletal Disorders},
  year={2006},
  volume={7},
  pages={62 - 62}
}
BACKGROUND Transcutaneous in vivo electroporation is expected to be an effective gene-transfer method for promoting bone regeneration using the BMP-2 plasmid vector. To promote enhanced osteoinduction using this method, we simultaneously transferred cDNAs for BMP-2 and BMP-7, as inserts in the non-viral vector pCAGGS. METHODS First, an in vitro study was carried out to confirm the expression of BMP-2 and BMP-7 following the double-gene transfer. Next, the individual BMP-2 and BMP-7 plasmids… CONTINUE READING
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