Simultaneous folate intake may prevent advers effect of valproic acid on neurulating nervous system

@article{Umur2011SimultaneousFI,
  title={Simultaneous folate intake may prevent advers effect of valproic acid on neurulating nervous system},
  author={Ahmet Sukru Umur and Mehmet Selçuki and Adem Bursali and Nurcan Umur and Burcu Kara and H. Seda Vatansever and Yusuf Kurtuluş Duransoy},
  journal={Child's Nervous System},
  year={2011},
  volume={28},
  pages={729-737}
}
PurposeThe aim of this study is to elucidate the preventive effect of folic acid (FA) on teratogenic effects of valporic acid (VA) in early stage chick embryos on neural tube development.Materials and methodsOne hundred and fifty specific pathogen–free (SPF) chick eggs were used to investigate the neurulation in five groups. Group A was the control group. Group B was injected 0.02 ml of saline (0.9% NaCl) and was used for sham group. VA (0.72 mg) in 0.02 ml saline was injected in Group C, and 0… 
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A 26-year-old woman is taking valproic acid for her stable Juvenile Myoclonic Epilepsy and is taking prenatal vitamins since she is sexually active, and would recommend higher dose of folic acid to her.
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