Simultaneous folate intake may prevent advers effect of valproic acid on neurulating nervous system

  title={Simultaneous folate intake may prevent advers effect of valproic acid on neurulating nervous system},
  author={Ahmet Sukru Umur and M. Selçuki and Adem Bursali and N. Umur and B. Kara and H. Seda Vatansever and Yusuf Kurtulus Duransoy},
  journal={Child's Nervous System},
  • Ahmet Sukru Umur, M. Selçuki, +4 authors Yusuf Kurtulus Duransoy
  • Published 2011
  • Medicine
  • Child's Nervous System
  • PurposeThe aim of this study is to elucidate the preventive effect of folic acid (FA) on teratogenic effects of valporic acid (VA) in early stage chick embryos on neural tube development.Materials and methodsOne hundred and fifty specific pathogen–free (SPF) chick eggs were used to investigate the neurulation in five groups. Group A was the control group. Group B was injected 0.02 ml of saline (0.9% NaCl) and was used for sham group. VA (0.72 mg) in 0.02 ml saline was injected in Group C, and 0… CONTINUE READING
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