Simultaneous expression of thyroid peroxidase and human leukocyte antigen-DR by human thyroid cells: modulation by thyrotropin, thyroid-stimulating antibody, and interferon-gamma.

@article{Chiovato1994SimultaneousEO,
  title={Simultaneous expression of thyroid peroxidase and human leukocyte antigen-DR by human thyroid cells: modulation by thyrotropin, thyroid-stimulating antibody, and interferon-gamma.},
  author={Luca Chiovato and Paola Lapi and Perspectives Mariotti and Gianfranco Del Prete and Marco De Carli and Bracco S.p.A. Aldo Pinchera},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 2},
  pages={
          653-6
        }
}
Major histocompatibility class II molecules human leukocyte antigen-DR (HLA-DR) are abnormally expressed by human thyroid cells (HTC) in autoimmune thyroid glands. The simultaneous expression of HLA-DR and organ-specific autoantigens such as thyroid peroxidase (TPO) by HTC might enable these cells to function as antigen-presenting cells, thus perpetuating the autoimmune process. The aim of the present study was to clarify the interplay of endocrine (TSH) and immune [TSab or interferon-gamma… CONTINUE READING
BETA