Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas

@article{Takeda2004SimultaneousEO,
  title={Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas},
  author={Hiroaki Takeda and Hideto Miyoshi and Yoshitaka Tamai and Masanobu Oshima and Makoto Mark Taketo},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={701 - 704}
}
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E2 synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1+/−, Smad4+/− and Cdx2+/−mice. These results suggest that PGE2 produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas. 
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