Simultaneous donor marrow cell transplantation with reduced intensity conditioning prevents tracheal allograft obliteration in a bronchiolitis obliterans murine model.

@article{Nusair2005SimultaneousDM,
  title={Simultaneous donor marrow cell transplantation with reduced intensity conditioning prevents tracheal allograft obliteration in a bronchiolitis obliterans murine model.},
  author={Samir Nusair and Reuven Or and Samer Junadi and Gail Amir and Raphael Breuer},
  journal={Chest},
  year={2005},
  volume={128 6},
  pages={4024-9}
}
STUDY OBJECTIVES Prolonged survival of transplanted kidney or liver allografts has been associated with prolonged chimerism resulting from donor-origin leukocytes carried within the allograft parenchyma. The present study, performed in a murine model, examined whether simultaneous administration of donor bone marrow cells after reduced intensity conditioning allows acceptance of heterotopic tracheal allografts and prevents the formation of the airway fibroproliferative lesion, which mimics… CONTINUE READING