Simultaneous determination of trimipramine and its demethylated metabolites in plasma by gas chromatography-mass spectrometry.

@article{Bougerolle1985SimultaneousDO,
  title={Simultaneous determination of trimipramine and its demethylated metabolites in plasma by gas chromatography-mass spectrometry.},
  author={A. M. Bougerolle and Jean Louis Chabard and Mohamed Jbilou and H. Bargnoux and Jeannine Petit and J. Alfred Berger and G{\'e}rard Dordain},
  journal={Journal of chromatography},
  year={1985},
  volume={434 1},
  pages={
          232-8
        }
}
Abstract A capillary column gas chromatography—mass fragmentographic method for metapramine and its three major demethylated metabolites is described. Compounds are extracted from plasma using a double-extraction procedure and transformed into N-trifluoroacetyl derivatives. The detection is performed by monitoring specific ions for metapramine and for its metabolites with a mass detector. In spite of extensive metabolism in the liver and rapid elimination of metapramine, plasma concentrations… CONTINUE READING
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