Simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatography.

Abstract

The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetyl-sulphamethoxazole in serum and urine by high-performance liquid chromatography using sulphafurazole as internal standard is described. The separation was achieved on a reversed-phase column employing acetic acid-methanol as the mobile phase with spectrophotometric detection at… (More)

Topics

Cite this paper

@article{Gochin1981SimultaneousDO, title={Simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatography.}, author={R J Gochin and Isadore Kanfer and J. R. M. Haigh}, journal={Journal of chromatography}, year={1981}, volume={223 1}, pages={139-45} }