Simultaneous determination of tiopronin and d-penicillamine in human urine by liquid chromatography with ultraviolet detection.

@article{Kumierek2007SimultaneousDO,
  title={Simultaneous determination of tiopronin and d-penicillamine in human urine by liquid chromatography with ultraviolet detection.},
  author={Krzysztof Kuśmierek and Edward Bald},
  journal={Analytica chimica acta},
  year={2007},
  volume={590 1},
  pages={132-7}
}
d-Penicillamine and tiopronin are drugs widely used for the treatment of many diseases. Because of the relatively high frequency of side effects to these compounds, some of which are dose-related, drug monitoring in urine samples during treatment is advisable. In this paper, we describe a simple method for the determination of tiopronin and d-penicillamine in human urine. The method was based on derivatization with 2-chloro-1-methylquinolinium tetrafluoroborate followed by ion-pairing reversed… CONTINUE READING
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