Simultaneous determination of spironolactone and its metabolites in human plasma.

@article{Jankowski1996SimultaneousDO,
  title={Simultaneous determination of spironolactone and its metabolites in human plasma.},
  author={A. Jankowski and A. Skorek-Jankowska and H. Lamparczyk},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1996},
  volume={14 8-10},
  pages={
          1359-65
        }
}
This study describes a specific, precise, sensitive and accurate method for determination of unchanged spironolactone and its major active metabolites in human plasma. After one-step liquid-liquid extraction, analysis of the parent drug and its metabolites was performed in one chromatographic run, using a high performance liquid chromatography (HPLC) method with a programmed switchover of the UV wavelength. Spironolactone and 7 alpha-thiomethyl-spironolactone were detected at 245 nm, while… Expand
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