Simultaneous determination of sitagliptin and simvastatin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

Abstract

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and validated for simultaneous quantification of sitagliptin and simvastatin in human plasma. Carbamazepine was used as an internal standard (IS). The analytes and IS were extracted from the human plasma by liquid-liquid extraction… (More)
DOI: 10.1002/bmc.2751

Cite this paper

@article{Burugula2013SimultaneousDO, title={Simultaneous determination of sitagliptin and simvastatin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.}, author={Laxminarayana Burugula and Ramesh Mullangi and Nageswara Rao Pilli and Ajitha Makula and Durga Srinivas Lodagala and Rajnarayana Kandhagatla}, journal={Biomedical chromatography : BMC}, year={2013}, volume={27 1}, pages={80-7} }