Simultaneous determination of sample thickness, tilt, and electron mean free path using tomographic tilt images based on Beer-Lambert law.

@article{Yan2015SimultaneousDO,
  title={Simultaneous determination of sample thickness, tilt, and electron mean free path using tomographic tilt images based on Beer-Lambert law.},
  author={Rui Yan and Thomas Edward James Edwards and Logan M Pankratz and Richard J Kuhn and Jason Lanman and Jun Liu and Wen Jiang},
  journal={Journal of structural biology},
  year={2015},
  volume={192 2},
  pages={
          287-96
        }
}
Cryo-electron tomography (cryo-ET) is an emerging technique that can elucidate the architecture of macromolecular complexes and cellular ultrastructure in a near-native state. Some important sample parameters, such as thickness and tilt, are needed for 3-D reconstruction. However, these parameters can currently only be determined using trial 3-D reconstructions. Accurate electron mean free path plays a significant role in modeling image formation process essential for simulation of electron… CONTINUE READING
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