Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometry.

@article{Guo2012SimultaneousDO,
  title={Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometry.},
  author={Na Guo and Zhiwei Hu and Xiaoxu Fan and Jian Xu Zheng and Dehui Zhang and Tao Xu and Tao Yu and Yang Wang and Haiying Li},
  journal={Molecules},
  year={2012},
  volume={17 4},
  pages={4733-54}
}
Salidroside and its aglycone p-tyrosol are two major phenols in the genus Rhodiola and have been confirmed to possess various pharmacological properties. In our present study, p-tyrosol was identified as the deglycosylation metabolite of salidroside after intravenous (i.v.) administration to rats at a dose of 50 mg/kg, but was not detectable after intragastric gavage (i.g.) administration through HPLC-photodiode array detection (PDA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS… CONTINUE READING
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