Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.

@article{Trivedi2005SimultaneousDO,
  title={Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.},
  author={Rakesh Kumar Trivedi and Raja Reddy Kallem and Ramesh Mullangi and Nuggehally R. Srinivas},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2005},
  volume={39 3-4},
  pages={
          661-9
        }
}
A simple, sensitive and specific LC-MS/MS method for simultaneous determination of rosuvastatin (RST) and fenofibric acid (FFA) was developed and validated with 500 microL human plasma using carbamazepine as an internal standard (IS). The assay procedure involved a simple one-step liquid/liquid extraction of RST and FFA and IS from plasma into ethyl acetate. The organic layer was separated and evaporated under a gentle stream of nitrogen at 40 degrees C. The residue was reconstituted in the… CONTINUE READING

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