Simultaneous determination of raltegravir and raltegravir glucuronide in human plasma by liquid chromatography-tandem mass spectrometric method.

@article{Wang2011SimultaneousDO,
  title={Simultaneous determination of raltegravir and raltegravir glucuronide in human plasma by liquid chromatography-tandem mass spectrometric method.},
  author={Ling-zhi Wang and Lawrence Soon-U Lee and Win-Lwin Thuya and Gaik Hong Soon and Li-Ren Kong and P. Nye and Edmund Jon Deoon Lee and Charles Flexner and Boon-cher Goh},
  journal={Journal of mass spectrometry : JMS},
  year={2011},
  volume={46 2},
  pages={202-8}
}
Raltegravir is a highly efficacious inhibitor of HIV integrase. Large pharmacokinetic variability has been reported in clinical trials and this could be due to glucuronidation of raltegravir, the only reported metabolism pathway. In order to precisely evaluate and monitor the raltegravir and raltegravir glucuronide simultaneously, a novel, sensitive and robust liquid chromatography-tandem mass spectrometric method was developed and validated for simultaneous determination of raltegravir and… CONTINUE READING
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