Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.

@article{Inoue2014SimultaneousDO,
  title={Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.},
  author={Koichi Inoue and Daiju Hosaka and Nana Mochizuki and Hiroyasu Akatsu and Kaname Tsutsumiuchi and Yoshio Hashizume and Noriyuki Matsukawa and Takayuki Yamamoto and Toshimasa Toyo'oka},
  journal={Analytical chemistry},
  year={2014},
  volume={86 1},
  pages={797-804}
}
Typical markers of protein aging are spontaneous post-translational modifications such as amino acid racemization (AAR) and amino acid isomerization (AAI) during the degradation of peptides. The post-translational AAR and AAI could significantly induce the density and localization of plaque deposition in brain tissues. Alzheimer's disease (AD) is reliably related to the formation and aggregation of amyloid-β peptide (Aβ) plaques in the human brain. No current analytical methods can… CONTINUE READING

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