Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS).

@article{Szafarz2010SimultaneousDO,
  title={Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS).},
  author={Malgorzata Szafarz and Magdalena Lomnicka and Magdalena Sternak and Stefan Chlopicki and Joanna Szymura-Oleksiak},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2010},
  volume={878 11-12},
  pages={895-902}
}
A sensitive and specific liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous quantitation of nicotinic acid (NicA) and its metabolites nicotinamide (NA), 1-methylnicotinamide (MNA), 1-methyl-2-pyridone-5-carboxamide (M2PY) and 1-methyl-4-pyridone-5-carboxamide (M4PY) in rat plasma has been developed and validated. As an internal standard, 6-chloronicotinamide was used. The samples (100 microL) were subjected to deproteinization with acetonitrile… CONTINUE READING

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