Simultaneous determination of nerisopam, a novel anxiolytic agent showing polymorphic metabolism, and its N-acetyl metabolite from human plasma by a validated high performance liquid chromatographic method.

@article{Rna1996SimultaneousDO,
  title={Simultaneous determination of nerisopam, a novel anxiolytic agent showing polymorphic metabolism, and its N-acetyl metabolite from human plasma by a validated high performance liquid chromatographic method.},
  author={K{\'a}lm{\'a}n R{\'o}na and K R Ary and B{\'e}la Gach{\'a}lyi and Imre Klebovich and E Tomori},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1996},
  volume={678 1},
  pages={63-72}
}
A sensitive reversed-phase high-performance liquid chromatographic method with ultraviolet absorbance detection has been developed to simultaneously determine the concentrations of nerisopam (EGIS-6775) and its N-acetyl metabolite (EGIS-7649) from human plasma. The separation of the investigated compounds and internal standard was achieved on a Nucleosil 7… CONTINUE READING