Simultaneous determination of multiple amino acids in plasma in critical illness by high performance liquid chromatography with ultraviolet and fluorescence detection.

@article{Wang2013SimultaneousDO,
  title={Simultaneous determination of multiple amino acids in plasma in critical illness by high performance liquid chromatography with ultraviolet and fluorescence detection.},
  author={Hao Chun Wang and Yvette R. McNeil and Tsin W Yeo and Nicholas M Anstey},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2013},
  volume={940},
  pages={53-8}
}
There is increasing recognition that the host response to critical illness includes derangement of multiple amino acid pathways, including amino acids (AAs) central to metabolism and immune, endothelial and neurological function. To characterise concentration changes of these plasma amino acid we report the development and validation of a method for the quantification of AAs in small volumes of plasma (50μL) using HPLC with simultaneous UV and fluorescence (FL) detection. Protein precipitation… CONTINUE READING

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