Simultaneous determination of metapramine and its demethylated metabolites in plasma by gas chromatography-mass spectrometry.

@article{Bougerolle1985SimultaneousDO,
  title={Simultaneous determination of metapramine and its demethylated metabolites in plasma by gas chromatography-mass spectrometry.},
  author={A. M. Bougerolle and Jean Louis Chabard and H. Bargnoux and Jeannine Petit and J. Alfred Berger and G{\'e}rard Dordain},
  journal={Journal of chromatography},
  year={1985},
  volume={345 1},
  pages={
          59-66
        }
}
A capillary column gas chromatography--mass fragmentographic method for metapramine and its three major demethylated metabolites is described. Compounds are extracted from plasma using a double-extraction procedure and transformed into N-trifluoroacetyl derivatives. The detection is performed by monitoring specific ions for metapramine and for its metabolites with a mass detector. In spite of extensive metabolism in the liver and rapid elimination of metapramine, plasma concentrations of both… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…