Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography.

@article{Carlucci2000SimultaneousDO,
  title={Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography.},
  author={Giuseppe Carlucci and Giancarlo Palumbo and Pietro Mazzeo and Maria Giovanna Quaglia},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2000},
  volume={23 1},
  pages={185-9}
}
A method for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration range 3.0-7.0 microg ml(-1) for losartan and 0.5-2.0 microg ml(-1) for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 microg ml(-1) for losartan and 0.05 microg ml(-1) for hydrochlorothiazide. 

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