Simultaneous determination of haloperidol and its reduced metabolite in serum and plasma by isocratic liquid chromatography with electrochemical detection.

@article{Korpi1983SimultaneousDO,
  title={Simultaneous determination of haloperidol and its reduced metabolite in serum and plasma by isocratic liquid chromatography with electrochemical detection.},
  author={Esa R Korpi and Brian Phelps and Helen Granger and W- H Chang and Markku Linnoila and James L. Meek and Richard Jed Wyatt},
  journal={Clinical chemistry},
  year={1983},
  volume={29 4},
  pages={624-8}
}
We describe a liquid-chromatographic method for simultaneous quantification of haloperidol and its reduced metabolite in plasma and serum. Haloperidol and reduced haloperidol are concentrated from blood samples by liquid/liquid extraction into a hexane/isoamyl alcohol mixture, with chlorohaloperidol as the internal standard. For chromatographic separation we used a reversed-phase cyano-bonded column and a mobile phase of pH 6.8 phosphate buffer/acetonitrile (55/45 by vol). Haloperidol and its… CONTINUE READING

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