Simultaneous determination of four phenolic acids and seven alkaloids in rat plasma after oral administration of traditional Chinese medicinal preparation Jinqi Jiangtang Tablet by LC-ESI-MS/MS.

@article{Chang2016SimultaneousDO,
  title={Simultaneous determination of four phenolic acids and seven alkaloids in rat plasma after oral administration of traditional Chinese medicinal preparation Jinqi Jiangtang Tablet by LC-ESI-MS/MS.},
  author={Yan-Xu Chang and Ai-hua Ge and Xie-an Yu and Xiu-cheng Jiao and Jin Li and Jun He and Ji Wei Tian and Binh Yen Nguyen and John Teye Azietaku and Bo-Li Zhang and Xiumei Gao},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2016},
  volume={117},
  pages={
          1-10
        }
}
A rapid, sensitive and selective high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of four phenolic acids (neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and ferulic acid) and seven alkaloids (berberine, epiberberine, coptisine, magnoflorine, berberubine, palmatine and jatrorrhizine) in rat plasma. After mixing with the internal standards tetrahydropalmatine (IS1) and rosmarinic acid… CONTINUE READING

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