Simultaneous determination of four alkaloids in mice plasma and brain by LC-MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts.

@article{Gao2014SimultaneousDO,
  title={Simultaneous determination of four alkaloids in mice plasma and brain by LC-MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts.},
  author={Yuan Gao and Shuang Hu and Meng Zhang and Lilong Li and Yining Lin},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2014},
  volume={92},
  pages={6-12}
}
A sensitive and selective liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous determination of tetrahydropalmatine, coptisine, palmatine and dehydrocorydaline in mice plasma and brain after intraperitoneal administration of the extracts of Yuanhu Zhitong (YZ) and Corydalis Rhizoma (CR). Biological samples were processed with ethyl acetate extraction. The mobile phase consisted of acetonitrile and water (containing 10mM ammonium acetate, adjusted… CONTINUE READING
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Pharma - cokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

  • X. Lin, Y. Q. Miao, L. K. Meng, W. Chen, X. Tang
  • J . Pharm . Biomed . Anal .
  • 2012

Simultaneous determination of active flavonoids and alkaloids of Tang – Min – Ling – Pill in rat plasma by liquid chromatography tandem mass spectrometry

  • L. Tong, S. P. Zhou, H. Sun, K. S. Bi
  • J . Chromatogr . B
  • 2012

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