Simultaneous determination of five beta-lactam antibiotics in bovine milk using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

@article{Riediker2001SimultaneousDO,
  title={Simultaneous determination of five beta-lactam antibiotics in bovine milk using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.},
  author={Sonja Riediker and Richard H. Stadler},
  journal={Analytical chemistry},
  year={2001},
  volume={73 7},
  pages={1614-21}
}
A multiresidue method for the detection of five important beta-lactam antibiotics (amoxicillin, ampicillin, cloxacillin, oxacillin, penicillin G) in fresh milk is presented that allows quantitation of the analytes well below established legislative limits. The method avoids the use of acid during the extraction procedure and entails a cleanup step over a C18 cartridge. The analytes are separated and detected by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS… CONTINUE READING
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