Simultaneous determination of everolimus and cyclosporine concentrations by HPLC with ultraviolet detection.

@article{Baldelli2006SimultaneousDO,
  title={Simultaneous determination of everolimus and cyclosporine concentrations by HPLC with ultraviolet detection.},
  author={Sara Baldelli and Stefania Zenoni and Simona Merlini and Norberto Perico and Dario Cattaneo},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2006},
  volume={364 1-2},
  pages={354-8}
}
In the clinical practice of organ transplantation everolimus (RAD) is used in combination with cyclosporine (CsA), the most common antirejection agent. Both drugs show a narrow therapeutic window, which requires strict monitoring of their blood concentration. Simple methods for simultaneous measurement of RAD and CsA concentration are needed. As we have recently developed an HPLC-UV assay for RAD determination, we decided to implement it to allow concomitant measurement of CsA. The within- and… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…