Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies.

Abstract

A sensitive, simple and rapid high performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method was developed for simultaneous quantitation of epothilone D and its major metabolite, the hydrolytic metabolite, epothilone C as internal standard in human plasma. Plasma samples were precipitated with acetonitrile, the analysis used a Venusil… (More)
DOI: 10.1016/j.jchromb.2009.08.052

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@article{Zhang2009SimultaneousDO, title={Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies.}, author={Chunling Zhang and Lanjiao Zhao and Wenyuan Qi and Zhiyun Meng and Guoxiang Sun and Gui-fang Dou}, journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences}, year={2009}, volume={877 29}, pages={3748-52} }