Simultaneous determination of dipyridamole and salicylic acid in human plasma by high performance liquid chromatography-mass spectrometry.

@article{Wang2008SimultaneousDO,
  title={Simultaneous determination of dipyridamole and salicylic acid in human plasma by high performance liquid chromatography-mass spectrometry.},
  author={Nan Wang and Fengguo Xu and Zunjian Zhang and Cheng Yang and Xiuhong Sun and Jinheng Li},
  journal={Biomedical chromatography : BMC},
  year={2008},
  volume={22 2},
  pages={
          149-56
        }
}
A sensitive, rapid and simple high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) method for simultaneous determination of dipyridamole and salicylic acid in human plasma has been developed and validated. After the addition of diazepam and rosiglitazone as internal standard (IS), plasma samples were prepared by liquid-liquid extraction followed by an isocratic elution with methanol:2 mM ammonium acetate buffer (pH 4.25; 70/30, v/v) on a Shimadzu VP-ODS… CONTINUE READING