Simultaneous determination of cytosine arabinoside, daunorubicin and etoposide in human plasma.

@article{KroghMadsen2010SimultaneousDO,
  title={Simultaneous determination of cytosine arabinoside, daunorubicin and etoposide in human plasma.},
  author={Mikkel Krogh-Madsen and Steen Honor{\'e} Hansen and Per Hartvig Honor{\'e}},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2010},
  volume={878 22},
  pages={1967-72}
}
A method for simultaneous bioanalysis of the three cytotoxic drugs cytosine arabinoside, daunorubicin and etoposide in human plasma was developed and validated. A HPLC method with ultra-violet and fluorescence detection, preceded by mixed-mode cation-exchange solid phase extraction sample preparation, was used for the quantification of the analytes. The assay was used for the simultaneous measurement of cytosine arabinoside, daunorubicin and etoposide with linearity in the ranges of 13-1500 ng… CONTINUE READING