Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography.

@article{Hinz2003SimultaneousDO,
  title={Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography.},
  author={Burkhard Hinz and Daniel Auge and T. Rau and Stephan Rietbrock and Kay Brune and Ulrike Werner},
  journal={Biomedical chromatography : BMC},
  year={2003},
  volume={17 4},
  pages={
          268-75
        }
}
Aceclofenac [[2-(2',6'-dichlorophenyl)amino]phenylacetoxyacetic acid] is a phenylacetic acid derivative with potent analgesic and anti-inflammatory properties and an improved gastro-intestinal tolerance. In the present study, a liquid-liquid extraction-based reversed-phase HPLC method with UV detection was validated and applied for the analysis of aceclofenac and three of its metabolites (4'-hydroxy-aceclofenac, diclofenac, 4'-hydroxy-diclofenac) in human plasma. The analytes were separated… CONTINUE READING
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