Simultaneous determination of aceclofenac and diclofenac in human plasma by narrowbore HPLC using column-switching.

@article{Lee2000SimultaneousDO,
  title={Simultaneous determination of aceclofenac and diclofenac in human plasma by narrowbore HPLC using column-switching.},
  author={Jinseok Lee and C. K. Jeong and Sung Jin Choi and Sung Bae Kim and Mi Hye Lee and George Ko and Dong Hwan Sohn},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2000},
  volume={23 5},
  pages={775-81}
}
A fully automated narrowbore high performance liquid chromatography (HPLC) with column-switching was developed for the simultaneous determination of aceclofenac and diclofenac from human plasma samples. Plasma sample (100 microl) was directly introduced onto a Capcell Pak MF Ph-1 column (20 x 4 mm I.D.) where primary separation was occurred to remove proteins and concentrate target substances using acetonitrile potassium phosphate (pH 7, 0.1 M) (14:86, v/v). The drug molecules eluted from MF Ph… CONTINUE READING
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