Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection.

Abstract

A method for the simultaneous determination of Aprepitant, I (5-[[2(R)-[1(R)-(3,5-bistrifluoromethylphenyl)ethoxy]-3(S)-(4-fluorophenyl) morpholin-4-yl]methyl]-2,4-dihydro-[1,2,4]triazol-3-one) and two active metabolites (II and III) in human plasma has been developed. The method was based on high-performance liquid chromatography (HPLC) with atmospheric… (More)

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Cite this paper

@article{ChavezEng2004SimultaneousDO, title={Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection.}, author={Cynthia M Chavez-Eng and Marvin L. Constanzer and Bohdan Matuszewski}, journal={Journal of pharmaceutical and biomedical analysis}, year={2004}, volume={35 5}, pages={1213-29} }