Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics.

@article{Wang2009SimultaneousDO,
  title={Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics.},
  author={W. Wang and Chang-yin Li and X. Wen and Ping Li and L. Qi},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 8-9},
  pages={
          671-9
        }
}
  • W. Wang, Chang-yin Li, +2 authors L. Qi
  • Published 2009
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • A rapid high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed and validated for simultaneous quantification of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma after oral administration of ginger oleoresin. Plasma samples extracted with a liquid-liquid extraction procedure were separated on an Agilent Zorbax StableBond-C(18) column (4.6 mm x 50 mm, 1.8 microm) and detected by MS with electrospray ionization interface in positive selective ion… CONTINUE READING
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    References

    SHOWING 1-10 OF 41 REFERENCES
    High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages.
    • H. Schwertner, Deborah C Rios
    • Chemistry, Medicine
    • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
    • 2007
    • 112
    Quantitative determination of mitiglinide in human plasma by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
    • 16
    Pharmacokinetics of [6]-gingerol after intravenous administration in rats.
    • 45
    Metabolism of [6]-gingerol in rats.
    • 72
    • PDF
    Microsomal hydroxylation and glucuronidation of [6]-gingerol.
    • 37