Simultaneous detection of ketamine, lorazepam, midazolam and sufentanil in human serum with liquid chromatography-tandem mass spectrometry for monitoring of analgosedation in critically ill patients.

@article{Nosseir2014SimultaneousDO,
  title={Simultaneous detection of ketamine, lorazepam, midazolam and sufentanil in human serum with liquid chromatography-tandem mass spectrometry for monitoring of analgosedation in critically ill patients.},
  author={Nermine Samir Nosseir and Guido Michels and Patrick Binder and Martin H J Wiesen and Carsten H. G. M{\"u}ller},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2014},
  volume={973C},
  pages={
          133-141
        }
}
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination and quantification of four predominantly used analgosedatives in the intensive care unit: ketamine, lorazepam, midazolam and sufentanil in human serum. The extraction procedure consisted of protein precipitation of serum samples with… CONTINUE READING