Simultaneous detection of ABL1 mutation and IKZF1 deletion in Philadelphia chromosome-positive acute lymphoblastic leukemia using a customized target enrichment system panel.

@article{Aoe2018SimultaneousDO,
  title={Simultaneous detection of ABL1 mutation and IKZF1 deletion in Philadelphia chromosome-positive acute lymphoblastic leukemia using a customized target enrichment system panel.},
  author={Motoi Aoe and Hisashi Ishida and Takehiro Matsubara and Shuhei Karakawa and Hiroshi Kawaguchi and Keiichi Fujiwara and Kiichiro Kanamitsu and Kana Washio and Ken Okada and Misako Shibakura and Akira Shimada},
  journal={International journal of laboratory hematology},
  year={2018},
  volume={40 4},
  pages={
          427-436
        }
}
INTRODUCTION Recent clinical outcomes of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) vastly improved owing to tyrosine kinase inhibitor (TKI). However, the genetic status would be different in each case with ABL1 gene mutation or copy number variants (CNVs) such as IKZF1 deletion. In particular, the TKI resistant clone… CONTINUE READING