Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system.

@article{Zhang2015SimultaneousDO,
  title={Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system.},
  author={Qianyu Zhang and Rui Ran and Li Zhang and Yayuan Liu and Ling Mei and Zhirong Zhang and Huile Gao and Qin He},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={197},
  pages={
          208-18
        }
}
The roles of microRNAs (miRNAs) in the regulation of metastasis have been widely recognized in the recent years. Mir-10b antagomir (antagomir-10b) was shown to impede metastasis through the down-regulation of mir-10b; however, it could not stunt the growth of primary tumors. In this study we showed that the co-delivery of antagomir-10b with paclitaxel (PTX) by a novel liposomal delivery system modified with an anti-microbial peptide [D]-H6L9 (D-Lip) could significantly both hinder the migration… CONTINUE READING

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